LAUSR

Key Points Question Compared with medical therapy, is bariatric surgery with sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) associated with cost-effective weight reduction in patients with severe obesity and varying type 2 diabetes (T2D) severity? Findings In this economic evaluation using simulated patient cohorts, RYGB was projected to be the preferred strategy in the overall population with T2D at 5 years (probability preferred, 83.0%). The cost-effectiveness of RYGB was highest in those with mild-to-moderate T2D at baseline. Meaning These findings suggest that RYGB is projected to be cost-effective in patients with severe obesity and T2D, regardless of T2D severity.