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Sex differences in insulin sensitivity are present throughout the life‐span, with men having a higher prevalence of insulin resistance and diabetes compared with women. Differences in lean mass, fat mass,… Click to show full abstract
Sex differences in insulin sensitivity are present throughout the life‐span, with men having a higher prevalence of insulin resistance and diabetes compared with women. Differences in lean mass, fat mass, and fat distribution—particularly ectopic fat—have all been postulated to contribute to the sexual dimorphism in diabetes risk. Emerging data suggest ectopic lipid composition and subcellular localization are most relevant; however, it is not known whether they explain sex differences in obesity‐induced insulin resistance.
Journal Title: Obesity
Year Published: 2021
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