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Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting.

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A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in… Click to show full abstract

A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and cytotoxicity evaluation. The differential uptake, cellular internalization, negligible hemotoxicity, selective toxicity to MDA-MB-231 breast cancer cells, and the superior penetration in three-dimensional MDA-MB-231 tumorospheres confirm their utility as a promising delivery vector.

Keywords: peptide; tumor homing; combining tumor; molecular hybridization; hybridization combining; homing penetrating

Journal Title: Drug delivery and translational research
Year Published: 2021

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