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Microbial metabolite as icebreaker for immunotherapy.

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Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis… Click to show full abstract

Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8+ T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

Keywords: immunotherapy; icebreaker immunotherapy; cell; microbial metabolite; metabolite icebreaker

Journal Title: Cell metabolism
Year Published: 2022

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