Photo by eriic from unsplash
Abstract Herein, A novel strategy for Iron(II)-catalyzed alkynylation of thiohydantoins with terminal alkyne has been firstly reported. Optimization study was carried out through various catalysts, oxidants and solvents. The merit… Click to show full abstract
Abstract Herein, A novel strategy for Iron(II)-catalyzed alkynylation of thiohydantoins with terminal alkyne has been firstly reported. Optimization study was carried out through various catalysts, oxidants and solvents. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation. This study offers a unified method to access several alkynylated thiohydantoins in moderate to higher yield via C(sp3)-C(sp) bond formation.
Keywords:
iron catalyzed;
alkynylation thiohydantoins;
terminal alkyne;
catalyzed alkynylation;
thiohydantoins terminal
Journal Title: Tetrahedron Letters
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Tetrahedron Letters
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!