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Herein, we report that, by using chiral bicyclic bisborane catalysts, we have achieved the first highly regio-, diastereo-, and enantioselective direct asymmetric vinylogous Mannich reactions of acyclic α,β-unsaturated ketones. The… Click to show full abstract
Herein, we report that, by using chiral bicyclic bisborane catalysts, we have achieved the first highly regio-, diastereo-, and enantioselective direct asymmetric vinylogous Mannich reactions of acyclic α,β-unsaturated ketones. The strong Lewis acidity and steric bulk of the bisborane catalysts were essential for the observed high yields and selectivities.
Keywords:
acyclic unsaturated;
direct asymmetric;
asymmetric vinylogous;
reactions acyclic;
vinylogous mannich;
mannich reactions
Journal Title: Journal of the American Chemical Society
Year Published: 2021
Link to full text (if available)
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Journal Title: Journal of the American Chemical Society
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!