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0123456789();: while enabling prolonged retention and high cartilage penetration. Similar to EGFR overactivation, intra-articular delivery of these TGFα-conjugated nanoparticles in the knees of mice attenuated the development of surgery-induced OA.… Click to show full abstract
0123456789();: while enabling prolonged retention and high cartilage penetration. Similar to EGFR overactivation, intra-articular delivery of these TGFα-conjugated nanoparticles in the knees of mice attenuated the development of surgery-induced OA. “We are currently collaborating with other scientists to carry this project on into large animal models of OA,” says Qin. “If the TGFα-conjugated nanoparticles work in large animals, we then plan to initiate a human clinical trial.” Jessica McHugh
Journal Title: Nature Reviews Rheumatology
Year Published: 2021
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