A novel and facile copper-catalyzed direct coupling for the synthesis of diverse and functionalized 3-indolyl benzoxazin-2-ones from benzoxazin-2-ones and indoles has been developed. This new methodology offers an easy and… Click to show full abstract
A novel and facile copper-catalyzed direct coupling for the synthesis of diverse and functionalized 3-indolyl benzoxazin-2-ones from benzoxazin-2-ones and indoles has been developed. This new methodology offers an easy and rapid approach to a variety of 3-indolylbenzo[b][1,4]oxazin-2-ones in high yield. As an application of this protocol, a gram-scale synthesis of naturally occurring cephalandole A has also been accomplished.
Keywords:
benzoxazin ones;
ones indoles;
direct coupling;
synthesis diverse;
catalyzed direct;
copper catalyzed
Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
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Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!