This study addresses the structural basis of TIR-domain-mediated signal transduction in Toll-like receptor 2 pathways. It is demonstrated that TLR2, but not TLR1 or TLR6, TIR domains induce the formation… Click to show full abstract
This study addresses the structural basis of TIR-domain-mediated signal transduction in Toll-like receptor 2 pathways. It is demonstrated that TLR2, but not TLR1 or TLR6, TIR domains induce the formation of MyD88 TIR-domain assemblies in vitro. The MicroED structure of TLR2-induced MyD88 TIR assemblies determined at 2.85 Å resolution highlights conformational changes that are crucial for signaling and provides evidence that TLR2 can directly interact with MyD88 to initiate TLR signaling.
Keywords:
toll like;
tir;
tir domain;
like receptor;
myd88 tir
Journal Title: Acta Crystallographica Section D: Structural Biology
Year Published: 2024
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Journal Title: Acta Crystallographica Section D: Structural Biology
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!