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Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

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Recent advances in lipid research have revealed that impairments in lipid mediator signaling can be involved in the pathoetiology of a variety of diseases. We previously reported aberrant expression of… Click to show full abstract

Recent advances in lipid research have revealed that impairments in lipid mediator signaling can be involved in the pathoetiology of a variety of diseases. We previously reported aberrant expression of autotaxin, a key enzyme for lysophosphatidic acid (LPA) production, in placentas from women with preeclampsia. The present study aimed to further explore the involvement of LPA signaling in the pathoetiology of preeclampsia.

Keywords: placental expression; expression lysophosphatidic; expression; receptors normal; lysophosphatidic acid; acid receptors

Journal Title: American Journal of Reproductive Immunology
Year Published: 2019

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