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Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20‐hydroxyeicosatetraenoic acid (20‐HETE) action ameliorated ischemia/reperfusion… Click to show full abstract
Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20‐hydroxyeicosatetraenoic acid (20‐HETE) action ameliorated ischemia/reperfusion (I/R)‐induced AKI in rats. Now we tested the hypothesis that enhancement of epoxyeicosatrienoic acid (EET) actions may counteract the detrimental effects of 20‐HETE and prevent the initiation of AKI.
Keywords:
acute kidney;
ischemic acute;
epoxyeicosatrienoic acid;
kidney injury
Journal Title: Acta Physiologica
Year Published: 2019
Link to full text (if available)
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Journal Title: Acta Physiologica
Year Published: 2019
Link to full text (if available)
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recommendations!