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SMAD4 acts as a tumour suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC) patients. Although next‐generation sequencing (NGS) enabled us to detect numerous… Click to show full abstract
SMAD4 acts as a tumour suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC) patients. Although next‐generation sequencing (NGS) enabled us to detect numerous genetic alterations in a single assay, the clinical significance of SMAD4 alteration detected with NGS has not been fully investigated. The aim of this study was to evaluate the clinicopathological characteristics and clinical significance of SMAD4 alteration detected with NGS in CRC.
Keywords:
prognosis colorectal;
smad4;
poor prognosis;
colorectal cancer;
smad4 alteration
Journal Title: Histopathology
Year Published: 2019
Link to full text (if available)
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Journal Title: Histopathology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!