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Methods, precision, and analytical sensitivity of a novel low‐plasma‐volume assay of fibrinolytic capacity utilizing the euglobulin fraction

Fibrinolysis is a critical aspect of the hemostatic system, with assessment of fibrinolytic potential being critical to predict bleeding and clotting risk. We describe the method for a novel low‐plasma‐volume… Click to show full abstract

Fibrinolysis is a critical aspect of the hemostatic system, with assessment of fibrinolytic potential being critical to predict bleeding and clotting risk. We describe the method for a novel low‐plasma‐volume assay of fibrinolytic capacity utilizing the euglobulin fraction (the “modified mini‐euglobulin clot lysis assay [ECLA]”), its analytic sensitivity to alterations in key fibrinolytic substrates/regulators, and its initial applications in acute and convalescent disease cohorts.

Keywords: plasma volume; volume assay; low plasma; fibrinolytic capacity; novel low; assay fibrinolytic

Journal Title: International Journal of Laboratory Hematology
Year Published: 2024

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