LAUSR

Summary Optical coherence tomography angiography (OCT-A) might be a useful tool to describe different morphological findings in treatment-naive exudative AMD (eAMD) before and after VEGF-trap intravitreal injections. Trough a prospective case series of 60 consecutive treatment naive eAMD eyes diagnosed with different types of CNV a micro-structural analysis, based on 5 Activity Criteria (shape, branching pattern, presence of anastomoses, vessel's termini and presence of perilesional halo) was performed. Treatment-induced changes in choroidal neovascularization, CNV area and greatest linear dimension were assessed along with the variation in subretinal and/or intraretinal fluid. After treatment tiny branching vessels, anastomoses and peripheral arcades reduced from 100% of the cases to 40%, 50% and 30% respectively. Considering still-active lesions, persistent tiny vessels were observed in 75% of the cases, anastomoses in 60% of the cases and a residual activity of CNV was associated with a peripheral arcade in 100% of the cases. OCT-A Activity Criteria and quantitative findings, may help in the diagnosis of CNV, guiding decisions for treatment, as well as in monitoring the evolution of CNV and its response to treatment.