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Formulation and Statistical Evaluation of Tablets Containing Pitavastatin- Self Nano Emulsifying Drug Delivery Systems.

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PURPOSE To formulate and characterize tablets containing Pitavastatin that has been loaded with a self-nano emulsifying drug delivery system (SNEDDS). METHODS Pitavastatin SNEDDS were prepared with a variety of oils,… Click to show full abstract

PURPOSE To formulate and characterize tablets containing Pitavastatin that has been loaded with a self-nano emulsifying drug delivery system (SNEDDS). METHODS Pitavastatin SNEDDS were prepared with a variety of oils, surfactants, co-surfactants, and solvents to improve the dissolution rate and bioavailability of the HMG-CoA reductase inhibitor. The SNEDDS components were preliminarily investigated for drug solubility in various vehicles, excipient miscibility, emulsification rate, and ternary phase diagrams. The tablets were made using a porous carrier made of Aerosil 200 and then loaded with SNEDDS using a simple absorption method. Physical parameters such as tablet hardness, weight variation, disintegration, drug content, and in-vitro drug release were then measured on the tablets. RESULTS Labrafac Lipophilewl1349 (Oil), Tween 80 (Surfactant) and Egg lecithin (Co-surfactant) were selected for the preparation of SNEDDS. Tablets with high porosity suitable for loading with SNEDDS and containing the super-disintegrants, achieved complete dissolution of Pitavastatin from the tablets. In vitro release of Pitavastatin from SNEDDS and the tablets was similar (p < 0.05). CONCLUSION SNEDDS of Pitavastatin is a promising approach to achieving a solid dosage form of the liquid-loaded drug delivery systems for enhancing the solubility and dissolution rate of the drug, and hence also its bioavailability.

Keywords: tablets containing; containing pitavastatin; pitavastatin; drug delivery; drug

Journal Title: Current drug delivery
Year Published: 2022

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