Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.045
Abstract: The A2B adenosine receptor is a G protein-coupled receptor that belongs to the four member family of adenosine receptors: A1, A2A, A2B, A3. While adenosine-mediated A2B receptor signaling attenuates acute inflammation, facilitates tissue adaptation to… read more here.
Keywords: a2b receptor; adenosine receptor; a2b adenosine; structure ... See more keywords
Characterization of cancer-related somatic mutations in the adenosine A2B receptor.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173126
Abstract: In cancer, G protein-coupled receptors (GPCRs) are involved in tumor progression and metastasis. In this study we particularly examined one GPCR, the adenosine A2B receptor. This receptor is activated by high concentrations of its endogenous… read more here.
Keywords: a2b receptor; mutant receptors; pharmacology; cancer ... See more keywords
Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00849
Abstract: Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the… read more here.
Keywords: amazonensis; a2b receptor; mice; activation ... See more keywords
Irreversible Antagonists for the Adenosine A2B Receptor
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123792
Abstract: Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based on an 8-p-sulfophenylxanthine scaffold. Irreversible… read more here.
Keywords: irreversible a2bar; a2b receptor; a2bar; a2bar antagonists ... See more keywords