Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2020.0675
Abstract: Importance Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA-positive AAV and PR3-ANCA-positive… read more here.
Keywords: aav; vasculitis; cigarette smoking; anca positive ... See more keywords
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24363
Abstract: Adeno‐associated virus (AAV) vector‐mediated delivery of human α‐synuclein (α‐syn) gene in rat substantia nigra (SN) results in increased expression of α‐syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this… read more here.
Keywords: aav; substantia nigra; expression; downregulation ... See more keywords
A shared motif of hla-dpb1 affecting the susceptibility to pr3-anca positive granulomatosis with polyangiitis: comparative analysis of a Turkish cohort with matched healthy controls
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04789-4
Abstract: We aimed to analyse the distribution of HLA Class 2 genotypes which were reported among the genetic risk factors for ANCA-associated vasculitis (AAV) among Turkish patients in comparison with healthy subjects and previously reported data… read more here.
Keywords: pr3; aav; analysis; hla ... See more keywords
Response to: Biosimilars for vasculitis: promise requires validation by quality studies
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05381-0
Abstract: We thank Misra et al. for their interest in our paper on the role of similar biological rituximab in remission induction and maintenance in granulomatosis with polyangiitis [1, 2]. They reviewed the available published literature… read more here.
Keywords: rituximab; aav; quality; use ... See more keywords
Healthcare and economic burden of ANCA-associated vasculitis in Italy: an integrated analysis from clinical and administrative databases
Sign Up to like & getrecommendations! Published in 2020 at "Internal and Emergency Medicine"
DOI: 10.1007/s11739-020-02431-y
Abstract: ANCA-associated vasculitides (AAV) comprise a group of systemic vasculitides characterized by inflammation of small-sized blood vessels leading to multi-organ involvement. The worldwide annual incidence of AAV ranges from 1.2 to 3.3 cases per 100 000… read more here.
Keywords: italy; aav; economic burden; healthcare economic ... See more keywords
Prevalence and long-term monitoring of humoral immunity against adeno-associated virus in Duchenne Muscular Dystrophy patients.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.03.004
Abstract: Adeno-associated virus (AAV) vectors are promising candidates for gene therapy and have been explored as gene delivery vehicles in the treatment of Duchenne Muscular Dystrophy (DMD). Recent studies showed compelling evidence of therapeutic efficacy in… read more here.
Keywords: aav; muscular dystrophy; associated virus; adeno associated ... See more keywords
Adeno-Associated Virus (AAV) Vectors: Rational Design Strategies for Capsid Engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.09.004
Abstract: Adeno-associated virus (AAV) consists of a simple genome, infects mammalian cells, displays nonpathogenicity in humans, and spans an array of serotypes and variants bearing distinct tissue tropisms. These attributes lend AAV tremendous promise as a… read more here.
Keywords: aav; engineering; rational design; capsid engineering ... See more keywords
Engineering the AAV capsid to evade immune responses.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.01.002
Abstract: Gene therapy is progressively emerging as a promising and powerful therapeutic modality, and adeno-associated virus (AAV) is a major delivery vehicle for such therapies. Among the most significant challenges that limit AAV's utility, however, is… read more here.
Keywords: capsid evade; aav; engineering; aav capsid ... See more keywords
Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.113167
Abstract: Secondary degeneration following an initial injury to the central nervous system (CNS) results in increased tissue loss and is associated with increasing functional impairment. Unilateral partial dorsal transection of the adult rat optic nerve (ON)… read more here.
Keywords: aav; retinal ganglion; bdnf mutant; optic nerve ... See more keywords
Use of adeno-associated viruses to inhibit Glutaredoxin-1 in mouse skeletal muscle
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.015
Abstract: Glutaredoxin-1 (Glrx) is a cytosolic enzyme that reverses glutathione (GSH) adducts of protein thiols generated through oxidative post-translational modifications. GSH-adducts regulate cellular signaling and transcription factors. We previously found that after femoral artery ligation Glrx… read more here.
Keywords: skeletal muscle; aav; muscle; expression ... See more keywords
Dual and triple AAV delivery of large therapeutic gene sequences into the inner ear
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.107912
Abstract: Adeno-associated virus (AAV)-mediated gene therapy has evolved from the bench to the bedside, and is now considered the therapy of choice for certain inherited diseases. AAVs are attractive vectors for several reasons: they are nonpathogenic,… read more here.
Keywords: aav; dual triple; triple aav; inner ear ... See more keywords