AMP-independent activator of AMPK for treatment of mitochondrial disorders
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DOI: 10.1371/journal.pone.0240517
Abstract: Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved drug for treating mitochondrial disease.… read more here.
Keywords: independent activator; amp independent; treatment mitochondrial; treatment ... See more keywords
The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK
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DOI: 10.3390/md20070418
Abstract: The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (complex V)… read more here.
Keywords: mandelalide; activator ampk; indirect activator; mandelalide indirect ... See more keywords