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Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery.

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0 Published in 2018 at "ACS nano"

DOI: 10.1021/acsnano.8b03640

Abstract: Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However, cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are differentially trafficked in vivo via lipoproteins including LDL and VLDL. We hypothesized that… read more here.

Keywords: delivery; cholesterol; analyzing 2000; vivo drug ... See more keywords