Stimulating Transcription in Antibiotic-Tolerant Escherichia coli Sensitizes It to Fluoroquinolone and Nonfluoroquinolone Topoisomerase Inhibitors
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DOI: 10.1128/aac.01639-22
Abstract: Antibiotic tolerant bacteria and persistent cells that remain alive after a course of antibiotic treatment can foster the chronicity of infections and the development of antibiotic resistance. Elucidating how bacteria overcome antibiotic action and devising… read more here.
Keywords: escherichia coli; transcription; antibiotic tolerant; topoisomerase inhibitors ... See more keywords
Motility-Independent Formation of Antibiotic-Tolerant Pseudomonas aeruginosa Aggregates
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DOI: 10.1128/aem.00844-19
Abstract: In this work, we have investigated the role of bacterial motility with regard to antibiotic-tolerant bacterial aggregate formation. Previous work has convincingly demonstrated that P. aeruginosa flagellar motility promotes the formation of surface-adhered biofilms in… read more here.
Keywords: formation; aeruginosa; antibiotic tolerant; motility ... See more keywords
Identification of a Small Molecule Compound Active against Antibiotic-Tolerant Staphylococcus aureus by Boosting ATP Synthesis
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DOI: 10.3390/ijms24076242
Abstract: Antibiotic tolerance poses a threat to current antimicrobial armamentarium. Bacteria at a tolerant state survive in the presence of antibiotic treatment and account for persistence, relapse and recalcitrance of infections. Antibiotic treatment failure may occur… read more here.
Keywords: small molecule; tolerant; staphylococcus aureus; molecule compound ... See more keywords