APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-3389
Abstract: The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by… read more here.
Keywords: apobec3a apobec3b; apobec3b activities; atr inhibition; cancer ... See more keywords
BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
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DOI: 10.1186/s12915-018-0617-1
Abstract: BackgroundBase Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the efficient enrichment… read more here.
Keywords: base editing; reporter; apobec3a apobec3b; base ... See more keywords
The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19400
Abstract: APOBEC3B, in addition to other members of the APOBEC3 gene family, has recently been intensively studied due to its identification as a gene whose activation in cancer is responsible for a specific pattern of massively… read more here.
Keywords: apobec3a apobec3b; breast cancer; deletion; cancer ... See more keywords