Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization
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DOI: 10.1186/s13568-019-0749-x
Abstract: Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S. hygroscopicus ATCC 14891 strain was treated here… read more here.
Keywords: streptomyces hygroscopicus; production; ascomycin production; room temperature ... See more keywords