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   Articles with "basis inhibition" as a keyword



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Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO.

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recommendations! Published in 2020 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2020.05.019

Abstract: Novel antitubercular agents are urgently needed to combat the emergence of global drug resistance to human tuberculosis (TB). Mycobacterial membrane protein Large 3 (MmpL3) is a promising drug target because its activity is essential and… read more here.

Keywords: structural basis; basis inhibition; 349 spiro; drug ... See more keywords
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Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: insights into biophysical and structural studies.

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recommendations! Published in 2020 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2020.111319

Abstract: Schistosoma japonicum glutathione transferase (Sj26GST), an enzyme central to detoxification of electrophilic compounds in the parasite, is upregulated in response to drug treatment. Therefore, Sj26GST may serve as a potential therapeutic target for the treatment… read more here.

Keywords: japonicum glutathione; sj26gst; basis inhibition; schistosoma japonicum ... See more keywords
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Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-25284-1

Abstract: Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies there is no therapeutic regimen for this deltaretrovirus. Here, we screened a library… read more here.

Keywords: htlv; structural basis; basis inhibition; deltaretroviral intasome ... See more keywords

Structural Basis of Inhibition of DCLK1 by Ruxolitinib

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22168488

Abstract: Given the functional attributes of Doublecortin-like kinase 1 (DCLK1) in tumor growth, invasion, metastasis, cell motility, and tumor stemness, it is emerging as a therapeutic target in gastrointestinal cancers. Although a series of specific or… read more here.

Keywords: dclk1 ruxolitinib; structural basis; ruxolitinib; basis inhibition ... See more keywords
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Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

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recommendations! Published in 2017 at "eLife"

DOI: 10.7554/elife.21347

Abstract: Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade… read more here.

Keywords: structural basis; cyrpa; basis inhibition; invasion ... See more keywords