Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.
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DOI: 10.1021/acsmedchemlett.7b00494
Abstract: Dysregulation of calpains 1 and 2 has been implicated in a variety of pathological disorders including ischemia/reperfusion injuries, kidney diseases, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). 2-(3-Phenyl-1H)-pyrazol-1-yl)nicotinamides represent a series of… read more here.
Keywords: novel; calpain inhibitors; metabolic liability; carbonyl reduction ... See more keywords