Adeno-Associated Virus (AAV) Vectors: Rational Design Strategies for Capsid Engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.09.004
Abstract: Adeno-associated virus (AAV) consists of a simple genome, infects mammalian cells, displays nonpathogenicity in humans, and spans an array of serotypes and variants bearing distinct tissue tropisms. These attributes lend AAV tremendous promise as a… read more here.
Keywords: aav; engineering; rational design; capsid engineering ... See more keywords
Adeno-associated virus (AAV) capsid engineering in liver-directed gene therapy
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2021.1865303
Abstract: ABSTRACT Introduction: Gene therapy clinical trials with adeno-associated virus (AAV) vectors report impressive clinical efficacy data. Nevertheless, challenges have become apparent, such as the need for high vector doses and the induction of anti-AAV immune… read more here.
Keywords: aav; vector; capsid engineering; therapy ... See more keywords