Polymyxin Binding to the Bacterial Outer Membrane Reveals Cation Displacement and Increasing Membrane Curvature in Susceptible but Not in Resistant Lipopolysaccharide Chemotypes.
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DOI: 10.1021/acs.jcim.7b00271
Abstract: Lipid-A is the causative agent of Gram-negative sepsis and is responsible for an increasingly high mortality rate among hospitalized patients. Compounds that bind Lipid-A can limit this inflammatory process. The cationic antimicrobial peptide polymyxin B… read more here.
Keywords: binding bacterial; bacterial outer; outer membrane; membrane curvature ... See more keywords