Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
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DOI: 10.2210/pdb6oi8/pdb
Abstract: A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. We have applied physicochemica... read more here.
Keywords: mechanistic characterization; optimization mechanistic; characterization pyridopyrimidine; pyridopyrimidine inhibitors ... See more keywords