Temperature Down‐Shift Modifies Expression of UPR‐/ERAD‐Related Genes and Enhances Production of a Chimeric Fusion Protein in CHO Cells
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DOI: 10.1002/biot.202000081
Abstract: Low culture temperature enhances the cell‐specific productivity of Chinese hamster ovary (CHO) cells expressing varied recombinant (r‐) proteins, but the mechanisms remain unclear. Regulation of unfolded protein response (UPR) pathway genes, such as transcriptional regulatory… read more here.
Keywords: protein; chimeric fusion; culture temperature; production ... See more keywords