Novel insecticidal 1,6-dihydro-6-iminopyridazine derivatives as competitive antagonists of insect RDL GABA receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6911
Abstract: BACKGROUND The ionotropic γ-aminobutyric acid (GABA) receptor (iGABAR) is an important target for insecticides and parasiticides. Our previous studies showed that competitive antagonists (CAs) of insect iGABARs have the potential to be used for developing… read more here.
Keywords: novel insecticidal; gaba; insecticidal dihydro; studies showed ... See more keywords
Meta-analysis of competitive antagonists in asthma treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of palliative medicine"
DOI: 10.21037/apm-21-412
Abstract: BACKGROUND This meta-analysis was developed to explore the efficacy of using antagonists to the chemokine receptor of T helper type 2 (Th2) cells (CRTH2) in the treatment of asthma, so as to provide theoretical foundation… read more here.
Keywords: meta analysis; control; analysis; treatment ... See more keywords
Research progress of purine competitive antagonists.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666221006112458
Abstract: Purine, one of nucleotide, is an important substance for metabolism regulation of the body. Purine plays a key role not only in the composition of coenzymes but also in the supply of energy. Since purine… read more here.
Keywords: chemistry; purine competitive; purine; competitive antagonists ... See more keywords
MPL Adjuvant Contains Competitive Antagonists of Human TLR4
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.577823
Abstract: Monophosphoryl lipid A (MPL®) is the first non-alum vaccine adjuvant to achieve widespread clinical and market acceptance, a remarkable achievement given that it is manufactured from a Salmonella enterica endotoxin. To understand how MPL® successfully… read more here.
Keywords: human tlr4; antagonists human; mpl; mpl adjuvant ... See more keywords
Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082479
Abstract: The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases. Deciphering the structural properties of kainate receptor ligands is crucial… read more here.
Keywords: structural studies; experimental computational; computational structural; competitive antagonists ... See more keywords