An Orthogonal Approach for Determination of Acetamide Content in Pharmaceutical Drug Substance and Base-Contaminated Acetonitrile by GC and GC-MS External Method.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmz077
Abstract: Acetamide is a potential genotoxic impurity; it should control in drug substance based on daily dosage level. It forms from base-contaminated acetonitrile and by-product of some drug substances. The available methods for acetamide in drug… read more here.
Keywords: drug; contaminated acetonitrile; drug substance; base contaminated ... See more keywords