Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.21776
Abstract: Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying… read more here.
Keywords: retrograde transport; autophagic stress; alzheimer disease; stress ... See more keywords