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Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain.

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0 Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.103991

Abstract: CREB-binding protein (CBP) is a large multi-domain protein containing a HAT domain catalyzing transacetylation and a bromodomain responsible for acetylated lysine recognition. CBPs could act as transcription co-activators to regulate gene expression and have been… read more here.

Keywords: design synthesis; cbp bromodomain; cpin711 showed; cpin7 ... See more keywords