Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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DOI: 10.1101/2022.01.04.474894
Abstract: RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds,… read more here.
Keywords: lztr1 loss; loss function; rit1 orthologs; dependency rit1 ... See more keywords