Mast Cells as Drivers of Disease and Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in immunology"
DOI: 10.1016/j.it.2017.10.005
Abstract: Mast cells (MCs) contribute to the pathogenesis of a multitude of diseases that include MC-driven disorders such as urticaria, type I allergies, and mastocytosis as well as autoimmune and other inflammatory disorders and malignant tumors.… read more here.
Keywords: mast cells; therapeutic targets; disease therapeutic; cells drivers ... See more keywords
Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136078
Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma, which leads to progressive loss of neurons… read more here.
Keywords: dysfunction alzheimer; alzheimer disease; disease; disease therapeutic ... See more keywords
Modeling the dynamics of innate immune response to Parkinson disease with therapeutic approach
Sign Up to like & getrecommendations! Published in 2022 at "Physical Biology"
DOI: 10.1088/1478-3975/ac8516
Abstract: This paper aims to mathematically model the dynamics of Parkinson’s disease with therapeutic strategies. The constructed model consists of five state variables: healthy neurons, infected neurons, extracellular α-syn, active microglia, and resting microglia. The qualitative… read more here.
Keywords: dynamics innate; extracellular syn; parkinson disease; disease therapeutic ... See more keywords
TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7805115
Abstract: Thioredoxin-interacting protein (TXNIP) was originally named vitamin D3 upregulated protein-1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX function and expression. TXNIP is an alpha-arrestin protein that is essential for… read more here.
Keywords: txnip; sword disease; double edged; disease therapeutic ... See more keywords
Human regulatory B cells in health and disease: therapeutic potential
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci85113
Abstract: Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such… read more here.
Keywords: human regulatory; disease; regulatory cells; health disease ... See more keywords
Astrocyte Reactivity in Alzheimer's Disease: Therapeutic Opportunities to Promote Repair.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666211029164106
Abstract: Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in Alzheimer's disease (AD), with the prominent presence of reactive astrocytes sur- rounding amyloid β- plaques, together with activated microglia. Reactive astrogliosis, implying… read more here.
Keywords: alzheimer disease; disease; therapeutic opportunities; disease therapeutic ... See more keywords
Therapeutic Strategies for Immune Transformation in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-223278
Abstract: Dysregulation of innate and adaptive immunity can lead to alpha-synuclein (α-syn) misfolding, aggregation, and post-translational modifications in Parkinson’s disease (PD). This process is driven by neuroinflammation and oxidative stress, which can contribute to the release… read more here.
Keywords: syn misfolding; therapeutic strategies; disease; parkinson disease ... See more keywords