2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.2015344
Abstract: Abstract In this study, different assortments of 2-arylquinolines and 2,6-diarylquinolines have been developed. Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as Topoisomerase I (TOP1) inhibitors with potent anticancer activity. Utilising the SAR outputs… read more here.
Keywords: inhibitory activity; molecular modelling; inhibition; activity ... See more keywords
EGFR/FAK and c-Src signaling pathways mediate the internalization of Staphylococcus aureus by osteoblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular microbiology"
DOI: 10.1111/cmi.13240
Abstract: Internalization of Staphylococcus aureus (S. aureus) in osteoblasts plays a critical role in the persistence and recurrence of osteomyelitis, the mechanisms involved in this process remain largely unknown. In the present study, evidence of internalized… read more here.
Keywords: egfr fak; internalization; aureus; fak src ... See more keywords
Overexpression of epidermal growth factor receptor and its downstream effector, focal adhesion kinase, correlates with papillary thyroid carcinoma progression
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12268
Abstract: Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between… read more here.
Keywords: expression; fak; egfr fak; downstream effector ... See more keywords