Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
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DOI: 10.1002/cbic.202200434
Abstract: Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular hostâguest chemistry, we complexed onto… read more here.
Keywords: bacteria supramolecular; chemically enhanced; enhanced immunogenicity; immunogenicity ... See more keywords
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
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DOI: 10.1158/2326-6066.cir-19-0467
Abstract: Compared to cytosolic antigens, mitochondrial tumor antigens prime a stronger antitumor immune response, instigated by enhanced cross-presentation and involvement of the STING pathway. Thus, cellular location of tumor antigens is relevant to improved cancer vaccine… read more here.
Keywords: enhanced immunogenicity; immunogenicity mitochondrial; cancer; localized proteins ... See more keywords