Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents
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DOI: 10.3389/fphar.2022.1014854
Abstract: 7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100–1000 folds more than irinotecan in vitro. However, the clinical application of SN38 has been limited due to the very narrow therapeutic window… read more here.
Keywords: glucose conjugates; highly potent; ethyl hydroxycamptothecin; colorectal cancer ... See more keywords