Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
Sign Up to like & getrecommendations! Published in 2020 at "Open Biology"
DOI: 10.1098/rsob.200282
Abstract: Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms.… read more here.
Keywords: cellular proteostasis; interactions cellular; exploiting interactions; prion ... See more keywords
Abstract 139: Exploiting interactions between ploidy and host physiology
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-139
Abstract: Whole-genome doubling facilitates rapid tumor evolution and is a hallmark of many cancers, including Glioblastoma (GBM) where it has an incidence of ~14%. GBM remains uniformly lethal, with a median overall survival of 14-16 months,… read more here.
Keywords: interactions ploidy; ploidy host; exploiting interactions; physiology ... See more keywords