Influence of the macromolecular crowder alginate in the fibrillar organization of the functional amyloid FapC from Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.109062
Abstract: Bacterial biofilms are an alternative lifestyle in which communities of bacteria are embedded in an extracellular matrix manly composed by polysaccharides, nucleic acids and proteins, being the hallmark of bacterial survival in a variety of… read more here.
Keywords: alginate; macromolecular crowder; functional amyloid; amyloid ... See more keywords
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05790a
Abstract: Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm, e.g. CsgA (E. coli) and FapC (Pseudomonas), is carefully regulated. However, it is unclear whether functional aggregation is inhibited by chaperones targeting… read more here.
Keywords: bacterial biofilm; primary nucleation; nucleation; fapc ... See more keywords
Solution-state NMR assignment and secondary structure propensity of the full length and minimalistic-truncated prefibrillar monomeric form of biofilm forming functional amyloid FapC from Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecular NMR Assignments"
DOI: 10.1101/2023.01.22.525107
Abstract: Functional bacterial amyloids provide structural scaffolding to bacterial biofilms. In contrast to the pathological amyloids, they have a role in vivo and are tightly regulated. Their presence is essential to the integrity of the bacterial… read more here.
Keywords: nmr assignment; state nmr; fapc; biofilm forming ... See more keywords