Expression of the Cyanobacterial FoF1 ATP Synthase Regulator AtpΘ Depends on Small DNA-Binding Proteins and Differential mRNA Stability
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DOI: 10.1128/spectrum.02562-21
Abstract: FoF1 ATP synthases produce ATP, the universal biological energy source. Under unfavorable conditions, ATP synthases can operate in a futile reverse reaction, pumping protons while ATP is used up. ABSTRACT FoF1 ATP synthases produce ATP,… read more here.
Keywords: fof1 atp; atpt; atp synthase; atp synthases ... See more keywords
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine
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DOI: 10.1371/journal.pntd.0005805
Abstract: Background Leishmaniasis is the world’s second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that… read more here.
Keywords: atp synthase; edelfosine; tumor cells; anticancer ... See more keywords
Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of FOF1-ATP synthase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1012008
Abstract: In addition to playing a central role in the mitochondria as the main producer of ATP, FOF1-ATP synthase performs diverse key regulatory functions in the cell membrane. Its malfunction has been linked to a growing… read more here.
Keywords: atp synthase; binding site; fof1 atp;
Mechanism of ADP-Inhibited ATP Hydrolysis in Single Proton-Pumping FoF1-ATP Synthase Trapped in Solution
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DOI: 10.3390/ijms24098442
Abstract: FoF1-ATP synthases in mitochondria, in chloroplasts and in most bacteria are the proton-driven membrane enzymes supplying the cells with ATP made from ADP and phosphate. To monitor and prevent the reverse chemical reaction of fast… read more here.
Keywords: atp synthase; atp hydrolysis; fof1 atp; hydrolysis single ... See more keywords
Cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation
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DOI: 10.7554/elife.69096
Abstract: In FoF1-ATP synthase, proton translocation through Fo drives rotation of the c-subunit oligomeric ring relative to the a-subunit. Recent studies suggest that in each step of the rotation, key glutamic acid residues in different c-subunits… read more here.
Keywords: among subunits; atp synthase; proton; rotation ... See more keywords