Diabetes-Associated Mutations in Proinsulin Provide a “Molecular Rheostat” of Nascent Foldability
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DOI: 10.1007/s11892-022-01447-2
Abstract: Purpose of Review Diabetes mellitus (DM) due to toxic misfolding of proinsulin variants provides a monogenic model of endoplasmic reticulum (ER) stress. The mutant proinsulin syndrome (also designated MIDY; Mutant INS -gene-induced Diabetes of Youth… read more here.
Keywords: foldability; proinsulin; cell; midy mutations ... See more keywords