FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Cell Biology"
DOI: 10.1038/s41556-025-01790-y
Abstract: Lipid droplets (LDs) are organelles that store and supply lipids, based on cellular needs. Although mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of LD neutral lipids to peroxidation and protective mechanisms… read more here.
Keywords: quality control; peroxidation; neutral lipid; lipid peroxidation ... See more keywords
NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02394-8
Abstract: RNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in acute myeloid leukemia (AML)… read more here.
Keywords: acute myeloid; ferroptosis; myeloid leukemia; fsp1 ... See more keywords
Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122412
Abstract: Glutathione peroxidase 4 (GPX4) has been reported as one of the major targets for ferroptosis induction, due to its pivotal role in lipid hydroperoxide removal. However, recent studies pointed toward alternative antioxidant systems in this… read more here.
Keywords: resistance ferroptosis; colon adenocarcinoma; fsp1; ferroptosis ... See more keywords