NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-019-09882-1
Abstract: K-Ras exists in two distinct structural conformations specific to binding of GDP and GTP nucleotides. The cycling between an inactive, GDP-bound state and an active, GTP-bound state is regulated by guanine nucleotide exchange factors and… read more here.
Keywords: human ras; resonance; ras; bound ... See more keywords
Abstract 5205: B6-KrasLSL-G12C mouse model for assessing the occurrence and development of lung and pancreatic cancer tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5205
Abstract: In May 2021, the FDA approved sotorasib (Lumakras™) as the first treatment for adult patients with non-small cell lung cancer (NSCLC) harboring the KRASG12C genetic mutation. To study the relationship between the mutational activation of… read more here.
Keywords: kraslsl g12c; g12c; pancreatic cancer; development ... See more keywords
Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation
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DOI: 10.3390/cancers13143572
Abstract: Simple Summary KRAS G12C mutations are important oncogenic mutations in lung cancer that can now be targeted by allosteric small molecule inhibitors. We assessed the imaging features and patterns of metastases in these lung cancers… read more here.
Keywords: g12c kras; imaging features; group; metastasis ... See more keywords