The metabolism and hepatotoxicity of ginkgolic acid (17 : 1) in vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(18)30124-9
Abstract: Pharmacological activities and adverse side effects of ginkgolic acids (GAs), major components in extracts from the leaves and seed coats of Ginkgo biloba L, have been intensively studied. However, there are few reports on their… read more here.
Keywords: ginkgolic acid; metabolism; metabolism hepatotoxicity; acid vitro ... See more keywords
Synthesis and Evaluation of Ginkgolic Acid Derivatives as SUMOylation Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00353
Abstract: SUMOylation has emerged as an important post-translational modification that has been shown to modulate protein activity associated with various signaling pathways, and consequently, it has emerged as an important therapeutic target. While several natural products… read more here.
Keywords: evaluation ginkgolic; sumoylation; synthesis evaluation; ginkgolic acid ... See more keywords
Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal food"
DOI: 10.1089/jmf.2021.k.0059
Abstract: Even though nasopharyngeal carcinoma (NPC) is not common worldwide, it is a major public health burden in endemic areas. Distant metastasis often leads to a poor prognosis for NPC; therefore, new and effective anticancer strategies… read more here.
Keywords: acid suppresses; carcinoma growth; apoptosis; ginkgolic acid ... See more keywords
Ginkgolic acid promotes inflammation and macrophage apoptosis via SUMOylation and NF-κB pathways in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1108882
Abstract: Background Excessive inflammation and increased apoptosis of macrophages contribute to organ damage and poor prognosis of sepsis. Ginkgolic acid (GA) is a natural constituent extracted from the leaves of Ginkgo biloba, that can regulate inflammation… read more here.
Keywords: apoptosis; sumoylation; inflammation macrophage; promotes inflammation ... See more keywords
Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073927
Abstract: Ginkgolic acid (C13:0) (GA), isolated from Ginkgo biloba, is a potential therapeutic agent for type 2 diabetes. A series of GA analogs were designed and synthesized for the evaluation of their structure–activity relationship with respect… read more here.
Keywords: type diabetes; type; ginkgolic acid; structure activity ... See more keywords
Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology reports"
DOI: 10.3892/or.2018.6786
Abstract: Liver cancer is one of the most devastating types of cancer worldwide. Despite years of improvements in treatment, the prognosis of patients with this type of malignancy remains poor due to frequent recurrence and metastasis… read more here.
Keywords: ginkgolic acid; invasion; hepg2 cells; hgf ... See more keywords