A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "Cell systems"
DOI: 10.1016/j.cels.2019.02.009
Abstract: G protein-coupled receptors (GPCRs) are central to how mammalian cells sense and respond to chemicals. Mammalian olfactory receptors (ORs), the largest family of GPCRs, mediate the sense of smell through activation by small molecules, though… read more here.
Keywords: multiplexed assay; scalable multiplexed; decoding gpcr; assay decoding ... See more keywords
Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15811
Abstract: G protein-coupled receptors modulate a plethora of physiological processes and mediate the effects of one-third of FDA-approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This 'biased signaling' paradigm… read more here.
Keywords: ligand bias; gpcr ligand; ligand; community guidelines ... See more keywords
A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20081970
Abstract: G protein-coupled receptors (GPCRs) are a main drug target and therefore a hot topic in pharmaceutical research. One important prerequisite to understand how a certain ligand affects a GPCR is precise knowledge about its binding… read more here.
Keywords: ligand binding; ligand; gpcr ligand; binding mode ... See more keywords