Sodium Butyrate Protects Against High Fat Diet‐Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25902
Abstract: Histone deacetylases are recently identified to act as key regulators for cardiac pathophysiology and metabolic disorders. However, the function of histone deacetylase (HDAC) in controlling cardiac performance in Type II diabetes and obesity remains unknown.… read more here.
Keywords: dysfunction; metabolic disorders; mice; hdac inhibition ... See more keywords
HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01636-x
Abstract: Despite the widespread use of the blockade of immune checkpoints, for a significant number of cancer patients, these therapies have proven ineffective, presumably due to the immunosuppressive nature of the tumor microenvironment (TME). Critical drivers… read more here.
Keywords: anti tumor; suppression; hdac inhibition; tumor ... See more keywords
DIPG-09. HDAC INHIBITION IN THALAMIC AND SPINAL CORD H3K27M+ DIFFUSE MIDLINE GLIOMA
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-oncology"
DOI: 10.1093/neuonc/noy059.102
Abstract: BACKGROUND Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the leading cause of brain tumor-related deaths in children. There are no effective treatments and median survival remains dismal. Genomics identified a mutation… read more here.
Keywords: diffuse; dipg hdac; diffuse midline; hdac inhibition ... See more keywords
Abstract 2366: HDAC inhibition improves immune checkpoint inhibitor efficacy in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2366
Abstract: Background: Immune checkpoint inhibitors have shown clinical benefit in solid tumors, including renal cell carcinoma (RCC); however, the rate of clinical response remains modest and improved therapeutic approaches need to be tested. Growing evidence suggests… read more here.
Keywords: immune checkpoint; hdac; hdac inhibition; cell ... See more keywords
Abstract 6252: HDAC inhibition increases Ewing sarcoma sensitivity to chemotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6252
Abstract: Purpose: The survival rate of those with Ewing sarcoma (ES) has seen very little improvement over the past several decades and remains dismal for those with recurrent or metastatic disease. Current treatment for Ewing sarcoma… read more here.
Keywords: cell; hdac inhibition; ewing sarcoma; analysis ... See more keywords
HDAC and PD-1 inhibition in humanized triple-negative breast cancer xenografts.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14604
Abstract: e14604Background: There is great interest in investigating immune checkpoint inhibition in combination with novel agents, however, preclinical studies are limited by the lack of immune-competent human cancer cell line xenograft models. We developed a “hematopoietic”… read more here.
Keywords: inhibition humanized; inhibition; hdac inhibition; cancer ... See more keywords
Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415506
Abstract: In animal studies, HDAC inhibitors such as butyrate have been reported to reduce plasma cholesterol, while conferring protection from diabetes, but studies on the underlying mechanisms are lacking. This study compares the influence of butyrate… read more here.
Keywords: hdac inhibition; cholesterol; butyrate; impaired srebp ... See more keywords