ABCA1 and HDL3 are required to modulate smooth muscle cells phenotypic switch after cholesterol loading.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.09.012
Abstract: BACKGROUND AND AIMS Cholesterol-loaded smooth muscle cells (SMCs) modify their phenotypic behavior becoming foam cells. To characterize the role of ABCA1 and HDL3 in this process, we evaluated HDL3 effects on cholesterol-induced phenotypic changes in… read more here.
Keywords: abca1; cholesterol; expression; hdl3 ... See more keywords
Enterically derived high-density lipoprotein restrains liver injury through the portal vein
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abe6729
Abstract: Intestinal HDL is hepatoprotective High-density lipoprotein (HDL) is important for cholesterol metabolism and may have anti-inflammatory and antimicrobial properties. Although HDL is mainly produced by the liver, the intestine is also a source. Han et… read more here.
Keywords: density lipoprotein; liver; pathology; hdl ... See more keywords
Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370217706966
Abstract: In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size… read more here.
Keywords: hdl2; scd plasma; blood; hdl3 ... See more keywords
Capacity of HDL to Efflux Cellular Cholesterol from Lipid-Loaded Macrophages Is Reduced in Patients with Familial Hypercholesterolemia
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DOI: 10.3390/metabo13020197
Abstract: This study aimed to evaluate the high-density lipoprotein (HDL) capacity to efflux cellular cholesterol from lipid-loaded macrophages to find a reliable and low-cost biomarker with the purpose of better evaluating the risk of premature cardiovascular… read more here.
Keywords: efflux cellular; capacity; capacity hdl; cholesterol ... See more keywords