HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes
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DOI: 10.3389/fimmu.2022.1067463
Abstract: Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and code for proteins that play a key role in guiding adaptive immune responses by presenting foreign and self peptides (ligands)… read more here.
Keywords: hla hla; hla; presentation; molecular functions ... See more keywords
Increased Prevalence of Unstable HLA-C Variants in HIV-1 Rapid-Progressor Patients
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DOI: 10.3390/ijms232314852
Abstract: HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with… read more here.
Keywords: hla; increased prevalence; progression; unstable hla ... See more keywords