Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.04.053
Abstract: Emergence of antibiotic-resistant bacteria constitutes an increasing threat to human health. For example, treatment options for Staphylococcus aureus infections is declining with the worldwide spreading of highly virulent community-associated methicillin-resistant S. aureus (CA-MRSA) strains. Anti-virulence therapy… read more here.
Keywords: agrc; autoinducing peptides; lactam hybrid; solonamide autoinducing ... See more keywords
Hybrid Analogues of Hydrazone and Phthalimide: Design, Synthesis, In vivo, In vitro, and In silico Evaluation as Analgesic Agents.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230517121726
Abstract: BACKGROUND Based on the anti-inflammatory and analgesic activity of hydrazone and phthalimide, a new series of hybrid hydrazone and phthalimide pharmacophores was prepared and evaluated as analgesic agents. METHODS The designed ligands were synthesized by… read more here.
Keywords: hybrid analogues; analgesic agents; cox; design ... See more keywords