Rational Design of an Orally Active Anticancer Fluoropyrimidine, Pencitabine, a Hybrid of Capecitabine and Gemcitabine.
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DOI: 10.1021/acsmedchemlett.1c00565
Abstract: The structure of the anticancer drug capecitabine was redesigned to prevent metabolic conversion to 5-fluorouracil and its associated potentially fatal toxicities. The resulting cytidine analogue, pencitabine, is a hybrid of capecitabine and gemcitabine, another anticancer… read more here.
Keywords: orally active; capecitabine gemcitabine; pencitabine hybrid; pencitabine ... See more keywords